Dave Whelan and Mike Di Scala met each other in Liverpool record shop 3 Beat Records and were both disc jockeys at nightclubs in the city. Di Scala had previously released music as a member of Rezonance Q and Ultrabeat and also as a solo artist. Dave Whelan hosted his own Jubilee club night since 2004 and the two were resident DJs at Society nightclub. They began producing music together as members of The Chosen Few, along with Les Calvert, and the trio also managed the Adhesive record label as a sublabel of All Around the World. The Chosen Few released a cover of the Tears for Fears song 'Everybody Wants to Rule the World' (Adhesive, 2004) and a remix of the original song appeared on Tears Roll Down (Greatest Hits 82–92).
As a duo Whelan and Di Scala released several remixes. In 2006, they released a remix of Running Up That Hill, entitled 'Boosh' as Da Mode. It was a limited release on 12" vinyl. After this release, they released various other remixes under various names such as The Bassline Hustlers and Men from Mars.
In 2010, they released their first recordings as CamelPhat on their own label Vice Records. As CamelPhat, the duo initially wore wrestling masks to conceal their identity because they "just wanted the people to judge the music and not us". They released numerous singles and EPs on various record labels and some CamelPhat songs appeared on the Ultratop charts in Belgium, such as 'The Act' (2014), 'Paradigm' featuring A*M*E (2015), 'Constellations' (2015), 'Make 'Em Dance' from Light Night EP (2016) and 'Hangin' Out with Charlie' from Hangin' with Charlie EP (2017).
The duo's collaboration with Elderbrook on 'Cola' (2017) was an international hit single which peaked at number one on the US Billboard Dance Club Songs chart and was nominated for Best Dance Recording at the 60th Annual Grammy Awards. In June 2019, they released 'Be Someone', a collaboration with Jake Bugg, as the lead single from their upcoming debut album.